High Quality Pharmaceutical Ingredient Ranitidine Hydrochloride CAS 66357-35-5

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: HB-Ranitidine Hydrochloride
• Suitable for: Adult
• State: Powder
• Purity: >98%
• Test: HPLC
• Packing: Rum, Aluminum Foil Bag
• MOQ: 100g
• Grade: Food Grade
• Shelf Life: 2 Years
• Storage: Cool Dry Place
• Color: White Powder
• Transport Package: Carton Box
• Specification: 99%
• Trademark: Haibo
• Origin: Shaanxi, China
• HS Code: 2932999099
• Production Capacity: 5000000/Year

Product Description

Ranitidine, N-[2-[[[5-(dimethylamino)methyl]-2-furanyl]methyl]thiol] ethyl]-N'-methyl-2-nitro-l,1-ethenediamine (Zantac), is a white solid, which inits hydrochloride salt form is highly soluble in water. It is anaminoalkyl derivative with pKa values of 2.7 (sidechain) and 8.2 (dimethylamino). Ranitidine is more potentthan cimetidine, but less potent than famotidine. Likeother H2-antagonists, it does not appear to bind to otherreceptors.
Bioavailability of an oral dose of ranitidine is about 50%and is not significantly affected by the presence of food.Some antacids may reduce ranitidine absorption and shouldnot be taken within 1 hour of administration of this drug. Theplasma half-life of the drug is 2 to 3 hours, and it is excretedalong with its metabolites in the urine. Three metabolites, ranitidineN-oxide, ranitidine S-oxide, and desmethyl ranitidine,have been identified. Ranitidine is only a weak inhibitor ofthe hepatic cytochrome isozymes, and recommended doses ofthe drug do not appear to inhibit the metabolism of otherdrugs. However, there have been isolated reports of drug interactions that suggest that ranitidinemay affect the bioavailability of certain drugs by someunidentified mechanism, perhaps by pH-dependent effect onabsorption or a change in volume of distribution.
In addition to being available in various dosage forms asthe hydrochloride salt, ranitidine is also available as a bismuthcitrate salt for use with the macrolide antibiotic clarithromycinin treating patients with an active duodenalulcer associated with H. pylori infection. Eradication of H.pylori reduces the risk of duodenal ulcer recurrence.
 

 

 

Analysi	Specifications	Result
Assay	≥99%	99.2%
Appearance	White powder	Complies
Loss on Drying	≤1.0%	0.04%
Ash	≤1.0%	0.1%
As	≤2.0ppm	<2.0ppm
Pb	≤2.0ppm	<2.0ppm
Insoluble impurity content	≤0.05%	Complies
Total Plate Count	≤1000 cfu/g	Complies
Yeast &. Mold	≤100 cfu/g	Complies
E.Coli	Negative	Negative
Salmonella	Negative	Negative
Conclusion	Conform USP Standard.
Storage condition	Store in cool & dry place, Keep away from strong light and heat.
Shelf life	2 years when properly stored.