Pharmaceutical Chemical Antizoan Veterinary Drug CAS 58-14-0 Pyrimethamine

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: HB-pyrimethamine
• Appearance: White Powder
• Sample: Available
• Storage: Cool Dry Place
• Shelf Life: 2 Years
• Transport Package: 25kg/Drum
• Specification: 99%
• Trademark: Haibo
• Origin: China
• HS Code: 0000
• Production Capacity: 5000kg/Month

Product Description

Pyrimethamine  is a synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins.
This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. Pyrimethamine is used with other medication (such as a sulfonamide) to treat a serious parasite infection (toxoplasmosis) of the body, brain, or eye or to prevent toxoplasmosis infection in people with HIV infection.
Pyrimethamine is a diaminopyrimidine which is structurally related to trimethoprim. It is effective against erythrocytic stage of Plasmodium (P) falciparum and less so against P. vivax, P. ovale and P. malariae. Pyrimethamine also inhibits the sporogony inthe mosquito, resulting in a decrease of transmission of the infection within the community.
The mechanism of action of pyrimethamine is related to its inhibition of dihydrofolic reductase necessary for the folic acid synthesis in the parasite. Pyrimethamine acts slowly and is not recommended as monotherapy for acute malaria attacks. Resistance to pyrimethamine developed soon when the drug was used on a large scale as monoprophylaxis. In resistant strains, the enzyme dihydrofolic reductase binds to pyrimethamine several hundred times less than in sensitive strains. This high grade resistance is probably a onestep mutation and cannot be overcome by increasing the dose. However, when combined with long-acting sulphonomides (sulphadoxine), the effect of pyrimethamine is potentiated and the risk of developing resistant strains is far less.

Analysi	Specifications
Assay	≥99%
Appearance	White powder
Loss on Drying	≤1.0%
Ash	≤1.0%
As	≤2.0ppm
Pb	≤2.0ppm
Insoluble impurity content	≤0.05%
Total Plate Count	≤1000 cfu/g
Yeast &. Mold	≤100 cfu/g
E.Coli	Negative
Salmonella	Negative
Conclusion	Conform USP Standard.
Storage condition	Store in cool & dry place, Keep away from strong light and heat.
Shelf life	2 years when properly stored.