Manufacturer Supply Naftifine Hydrochloride CAS 65473-14-5 Naftifine Hydrochloride Powder

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Adult
• State: Powder
• Purity: >98%
• Model NO.: HB-Naftifine Hydrochloride
• Appearance: White Powder
• Shelf Life: 2 Years
• Storage: Cool Dry Place
• Packing: Rum, Aluminum Foil Bag
• MOQ: 1kg
• CAS: 65473-14-5
• Sample: Available
• Transport Package: Rum, Aluminum Foil Bag
• Specification: 98%
• Trademark: Haibo
• Origin: Shaanxi, China
• HS Code: 2942000000
• Production Capacity: 50000/Pieces/Years

Product Description

Naftifine hydrochloride, also known as cinnamonyl methylaminne, naphthalennee, and naphthalennee hydrochloride, is currently one of the commonly used drugs for fungal infection in Department of Dermatology, belonging to the local antifungal agents of acrylamines. It has bactericidal effect on the dermatophytes (Trichophyton, Microsporum and epidermis Trichophyton). It has bacteriostasis against Malassezia, Candida and other yeasts. It also has local bactericidal effect on Gram-positive and negative bacteria. The mechanism of its action is to inhibit the fungal squalene cyclooxygenase. It interferes with the biosynthesis of ergosterol in fungal cell wall. It affects the lipid metabolism of fungi and causes the damage or death of fungal cells to play a bactericidal and bacteriostasis effect. It is suitable for dermatophytosis caused by sensitive fungi, such as tinea corporis, tinea pedis, tinea capitis, onychomycosis, tinea versicolor, superficial candidiasis as well as erasing fungal disease in the skin folds. For the the external application of 1% Naftifine Hydrochloride Ointment on the skin by thehealthy people, about 3% to 6% of the doses can be absorbed.The concentration of naphthofinn on the surface of the skin at a single dose within 24 hours is sufficient to inhibit the growth of dermatitis. Naftifine can be converted to at least three metabolites through the oxidation of benzene ring and naphthalenne and N- alkylation in the body. About 40% to 60% of the drugs in the body are excreted in the form of the original and metabolite form into the urine, and the rest is excreted into the feces by the bile. The half-life of the skin external use of naftifine is about 2~3 days.

 

 

Item	Test Standard		Testing Result
Appearance	98%		Complies
Color	White Powder		Complies
Particle Size	100% pass 80 mesh		Complies
Oder	Characteristic		Complies
Taste	Characteristic		Complies
Loss on Drying	≤5.0%		2.20%
Residue on Ignition	≤0.1%		0.05%
Residual	≤0.1%		Complies
Residual Ethanol	≤0.5%		Complies
Heave Mentals	≤10ppm		Complies
Na	≤0.1%		<0.1%
Pb	≤3 ppm		Complies
Total Plate	<1000CFU/g		Complies
Yeast & Mold	<100 CFU /g		Complies
E. Coli	Negative		Complies
Salmonella	Negative		Complies