| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
|
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In vitro, pirfenidone can inhibit the proliferation of uterine leiomyoma cells and leiomyoma cells. Pirfenidone inhibits the formation of collagen in TGF-β-1-induced fibroblasts. FGF and TGF-β-1 induced fibroblast proliferation. In the hamster model, pirfenidone, orally, prevents and treat bleomycin-induced pulmonary fibrosis. Pirfenidone can prevent chemically induced rat sclerosing peritonitis and can also be treated with keloid transplantation for nude mice. Pirrenidone 0.01 1 mg / ml can inhibit the matrix and dose-dependent manner of serum stimulation of uterine fibroids and leiomyoma cell DNA synthesis, the compound without cytotoxicity, the collagen mRNA levels have no effect. Pirfenidone in the hamster pulmonary fibrosis model can reduce the level of collagen I mRNA levels before the disease, reduce lung proline levels and malondialdehyde and lung preservation of amino acid hydroxylase activity. |
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Analysis
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Specification
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Result
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Test method
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Physical Description
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|
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| Appearance | White powder | White powder |
Visual
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Odor
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Characteristic
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Characteristic
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Organoleptic
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Particle size
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90% pass 80 mesh
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90% pass 80 mesh
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80 Mesh Screen
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Chemical Tests
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Assay (Lutein)
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99%
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90.15%
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HPLC
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Loss on drying
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5.0% Max
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1.82%
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5g/105ºC/2hrs
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Ash Contents
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5.0% Max
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1.12%
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2g/525ºC/3hrs
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Residual Solvents
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50.0 ppm, Only Ethanol
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<30.0 ppm
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/
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Heavy metals
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5.0 ppm Max
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<3.0 ppm
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AAS
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Lead
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3.0 ppm Max
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<1.0 ppm
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AAS
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Arsenic
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3.0 ppm Max
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<1.0 ppm
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AAS
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Microbiology Control
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Total Bacteria Count
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1,000cfu/g Max
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<280cfu/g
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AOAC
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Yeast & Mold
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100cfu/g Max
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<10cfu/g
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AOAC
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Coliform
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30.0 MPN/g Max
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<3.0 MPN/g
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AOAC
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Conclusion
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Complies with the standards.
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General Status
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Non-GMO, ISO Certificated.
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