| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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Acalabrutinib, also known as ACP-196, is an orally available Bruton tyrosine kinase (BTK) inhibitor with potential antitumor activity.When applied, ACP-196 inhibits BTK activity and blocks activation of the B cell antigen receptor (BCR) signaling pathway.This prevents B cell activation and BTK-mediated activation of downstream survival pathways.
This leads to inhibition of the growth of malignant B cells that overexpress BTK.BTK is a member of the Src associated BTK/TEC cytoplasmic tyrosine kinase family and is overexpressed in B-cell malignancies.It plays an important role in B lymphocyte development, activation, signaling, proliferation, and survival.
Supply Acalabrutinib ACP-196 Powder CAS 1420477-60-6 Acalabrutinib
| Item | Test Standard | Testing Result | |
| Assay | 99% | Complies | |
| Apperence | White Powder | Complies | |
| Particle Size | 100% pass 80 mesh | Complies | |
| Oder | Characteristic | Complies | |
| Taste | Characteristic | Complies | |
| Loss on Drying | ≤5.0% | 2.20% | |
| Residue on Ignition | ≤0.1% | 0.05% | |
| Residual | ≤0.1% | Complies | |
| Residual Ethanol | ≤0.5% | Complies | |
| Heave Mentals | ≤10ppm | Complies | |
| Na | ≤0.1% | <0.1% | |
| Pb | ≤3 ppm | Complies | |
| Total Plate | <1000CFU/g | Complies | |
| Yeast & Mold | <100 CFU /g | Complies | |
| E. Coli | Negative | Complies | |
| Salmonella | Negative | Complies | |
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