High Quarity Factory Supply Escitalopram CAS 128196-01-0

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Adult
• State: Powder
• Purity: >99%
• Model NO.: HB-Escitalopram
• Test: HPLC
• Packing: Rum, Aluminum Foil Bag
• MOQ: 1kg
• Grade: Food
• Shelf Life: 2 Years
• Storage: Cool Dry Place
• Transport Package: Carton Box
• Specification: 99%
• Trademark: Haibo
• Origin: Shaanxi, China
• HS Code: 00000000
• Production Capacity: 5000000/Year

Product Description

Escitalopram was launched as Cipralex in Switzerland, Sweden and UK for the treatment of depression and panic disorder. It is the S-enantiomer version of the selective serotonin reuptake inhibitor (SSRI) citalopram approved in 1989. It can be obtained from 5cyanophthalide by successive reactions with 4-fluorophenyl magnesium bromide and 3-(dimethylamino)propyl magnesium chloride. The resulting racemic diol can be resolved by several routes such as crystallization with a chiral acid. Finally, a two step cyclisation procedure affords escitalopram. Escitalopram is twice as effective as the racemate and over 100 fold more potent than the R-enantiomer in inhibiting the 5HT reuptake in vivo in rat brain synaptosomes. Moreover, it exhibits higher selectivity for the human serotonin transporter relative to the noradrenaline or dopamine transporters than any other currently available SSRl's. In the mouse forced swim test, the duration of immobility (which reflects antidepressant activity) for escitalopram was comparable to citalopram and greater than (R)-citalopram. Clinical trials in patients with panic disorders or depression have shown that escitalopram has a clinically relevant and significant effect. 
 

Items	Specifications	Results
Appearance	White Powder	Confirm
Odor& Taste	Characteristic	Confirm
Loss on drying	≤8.0%	2.8%
Assay(HPLC)	99.0% min	99.2%
Ash	≤1.0%	0.35%
Heavy Metal	≤10 ppm	Confirm
As	≤1.0ppm	Confirm
Pb	≤1.0ppm	Confirm
Cd	≤1.0ppm	Confirm
Hg	≤0.1ppm	Confirm
Total plate count	≤1000 cfu/g	Confirms
Yeast&Mold	≤100 cfu/g	Confirms
E.Coli	Negative	Negative
Salmonella	Negative	Negative
Staphylococcus aureus	Negative	Negative