Customization: | Available |
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Powder: | Yes |
Customized: | Customized |
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Camptothecin was isolated from the bark and branches of the Camptotheca acacia tree (Camptotheca acacia) native to China and was early used in traditional Chinese medicine to treat cancer. Camptothecin in preliminary clinical trials showed significant anticancer properties, low solubility and high adverse drug reaction characteristics. Medicinal chemists have taken advantage of these properties to develop a variety of synthetic camptothecin and various derivatives to increase the good effect.
Camptotheca acuminata (Camptotheca, Happy tree), a tree native to Hunan, Guangxi, Sichuan province of China. Camptotheca acuminata
used as a cancer treatment in Traditional Chinese Medicine. Generally, the leaves and the fruits of happy tree are applied for the
extraction of Camptothecin. Camptothecin (CPT) is a cytotoxic alkaloid originated from camtotheca acuminata or
Nothapodytes pittosporoides(Mappia). Camptothecin was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of
natural products for anticancer drugs.
1. Camptothecin showed remarkable anticancer activity in inhibiting the DNA enzyme topoisomerase I.
Items
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Specifications
|
Results
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Appearance
|
White powder |
Confirm
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Odor& Taste
|
Characteristic
|
Confirm
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Loss on drying
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≤8.0%
|
2.8%
|
Assay(HPLC)
|
10.0% min
|
10.2%
|
Ash
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≤1.0%
|
0.35%
|
Heavy Metal
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≤10 ppm
|
Confirm
|
As
|
≤1.0ppm
|
Confirm
|
Pb
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≤1.0ppm
|
Confirm
|
Cd
|
≤1.0ppm
|
Confirm
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Hg
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≤0.1ppm
|
Confirm
|
Total plate count
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≤1000 cfu/g
|
Confirms
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Yeast&Mold
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≤100 cfu/g
|
Confirms
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E.Coli
|
Negative
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Negative
|
Salmonella
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Negative
|
Negative
|
Staphylococcus aureus
|
Negative
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Negative
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