| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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Glipizide is an oral rapid- and short-acting anti-diabetic drug from the sulfonylurea class. It is classified as a second generation sulfonylurea, which means that it undergoes enterohepatic circulation. Second-generation sulfonylureas are both more potent and have shorter half-lives than the first-generation sulfonylureas.
Application:
Glipizide sensitizes the beta cells of pancreatic islets of Langerhans response, meaning that more is released in response to glucose than would be without glipizide ingestion.
Glipizide acts by partially blocking potassium channels among beta cells of pancreatic islets of Langerhans. By blocking potassium channels, the cell depolarizes, which results in the opening of voltage-gated calcium channels. The resulting calcium influx encourages release from beta cells.
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Tems |
Standards |
Results |
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Physical Analysis |
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Description |
White Powder | Complies |
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Assay |
99% | 99.6% |
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Mesh Size |
100 % pass 80 mesh | Complies |
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Ash |
≤ 5.0% | 2.85% |
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Loss on Drying |
≤ 5.0% | 2.65% |
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Chemical Analysis |
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Heavy Metal |
≤ 10.0 mg/kg |
Complies |
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Pb |
≤ 2.0 mg/kg |
Complies |
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As |
≤ 1.0 mg/kg | Complies |
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Hg |
≤ 0.1mg/kg | Complies |
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Microbiological Analysis |
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Residue of Pesticide |
Negative | Negative |
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Total Plate Count |
≤ 1000cfu/g | Complies |
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Yeast&Mold |
≤ 100cfu/g | Complies |
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E.coil |
Negative |
Negative |
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Salmonella |
Negative |
Negative |
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