| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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Axitinib is an anti-tumor drug and a multi-target small molecule inhibitor that can inhibit vascular endothelial cell receptors VEGFR1, VEGFR2, VEGFR3, platelet-derived receptor and c-KIT.
Function of axitinib
1.Axitinib (AG-013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.
2.Axitinib is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.
Application of axitinib
Axitinib is a small molecular inhibitor with multiple targets, and the main targets are VEGFR, kit, PDGFR and ret. It is white powder, with melting point of 218.4 ºC, slightly soluble in polyethylene glycol 400, slightly soluble in ethanol, extremely micro soluble in , almost insoluble in water...
| Item | Test Standard | Testing Result | |
| Assay | 99% | Complies | |
| Apperence | White Powder | Complies | |
| Particle Size | 100% pass 80 mesh | Complies | |
| Oder | Characteristic | Complies | |
| Taste | Characteristic | Complies | |
| Loss on Drying | ≤5.0% | 2.20% | |
| Residue on Ignition | ≤0.1% | 0.05% | |
| Residual | ≤0.1% | Complies | |
| Residual Ethanol | ≤0.5% | Complies | |
| Heave Mentals | ≤10ppm | Complies | |
| Na | ≤0.1% | <0.1% | |
| Pb | ≤3 ppm | Complies | |
| Total Plate | <1000CFU/g | Complies | |
| Yeast & Mold | <100 CFU /g | Complies | |
| E. Coli | Negative | Complies | |
| Salmonella | Negative | Complies | |
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