99% Purity Poloxamer 188 Pharmaceutical Raw Material Poloxamer 188

• Customization: Available
• CAS No.: 9003-11-6
• Formula: C5h10o2
• Model NO.: HB-Poloxamer 188
• EINECS: /
• Type: Poloxamer 188
• Appearance: Powder
• Quality: Industrial
• Colour: White
• Packing: Rum, Aluminum Foil Bag
• MOQ: 1kg
• Grade: Pharmaceutical Grade
• Shelf Life: 2 Years
• Storage: Cool Dry Place
• Color: White
• Transport Package: 1kg Per Foil Bag, 10 Bags Per Carton. 25 Kg Per Dr
• Specification: 99%
• Trademark: Haibo
• Origin: Shaanxi, China
• HS Code: 3402420000
• Production Capacity: 5000000/Year

Product Description

Product Name:Poloxamer 188
Because of its mild physical properties and stable chemical properties, poloxamer 188 is not only widely used in some traditional dosage forms such as suppositories, emulsions, tablets and gels, but also can form micelles to increase the solubility and stability of poorly soluble drugs, control the release rate of such drugs, and also has the function of restricting the efflux of efflux pumps and promoting the absorption of drugs by the body.

Uses: 1. Increase the dissolution of drugs. The dissolution rate and bioavailability of oral preparations of poorly soluble drugs can be greatly improved by preparing solid dispersants by melting or solvent method. It is an ideal carrier of quick-acting solid dispersant.

2. As emulsifier and stabilizer, poloxamer 188 can be used as a synthetic emulsifier for intravenous injection. Poloxamer 188 is a good emulsifier for preparing intravenous fat emulsion, which can form 0-box emulsifier with the dosage of 0.1%-0.5%.

3. As a cream, poloxamer 188, the matrix of suppository, can promote the absorption of drugs, and it can also play a role in slow release and delayed action when used as a matrix.

4. As an absorption enhancer, poloxamer 188 can slow down intestinal peristalsis, increase the retention time of drugs in gastrointestinal tract and increase absorption, thus improving the bioavailability of oral preparations. On the other hand, it has good compatibility with skin, increases skin permeability, and can promote the absorption of preparations for external use.

tems	Standards	Results
Physical Analysis
Description	White Powder	Complies
Assay	99%	99.6%
Mesh Size	100 % pass 80 mesh	Complies
Ash	≤ 5.0%	2.85%
Loss on Drying	≤ 5.0%	2.65%
Chemical Analysis
Heavy Metal	≤ 10.0 mg/kg	Complies
Pb	≤ 2.0 mg/kg	Complies
As	≤ 1.0 mg/kg	Complies
Hg	≤ 0.1mg/kg	Complies
Microbiological Analysis
Residue of Pesticide	Negative	Negative
Total Plate Count	≤ 1000cfu/g	Complies
Yeast&Mold	≤ 100cfu/g	Complies
E.coil	Negative	Negative
Salmonella	Negative	Negative