| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Classification: Antineoplastic, antimetabolite Action/Kinetics: An oral prodrug of 5'-deoxy-5-fluorouridine (5'DFUR) that is converted to 5-fluorouracil (5-FU).
1.FdUMP and the folate cofactor, N5-10-methylenetetrahydrofolate, bind to thymidylate synthase to form a covalently bound ternary complex which inhibits the formation of thymidylate from uracil. Thymidylate is essential for the synthesis of DNA so a deficiency inhibits cell division.
2. nuclear transcriptional enzymes can mistakenly incorporate FUTP in place of uridine triphosphate during RNA synthesis; this interferes with RNA processing and protein synthesis.
| Analysi | Specifications | |
| Assay | ≥99% | |
| Appearance | White powder | |
| Loss on Drying | ≤1.0% | |
| Ash | ≤1.0% | |
| As | ≤2.0ppm | |
| Pb | ≤2.0ppm | |
| Insoluble impurity content | ≤0.05% | |
| Total Plate Count | ≤1000 cfu/g | |
| Yeast &. Mold | ≤100 cfu/g | |
| E.Coli | Negative | |
| Salmonella | Negative | |
| Conclusion |
Conform USP Standard.
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| Storage condition |
Store in cool & dry place, Keep away from strong light and heat.
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| Shelf life |
2 years when properly stored.
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