High Grade Calcium Folinate CAS No 1492-18-8 Calcium Folinate

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: HB-Calcium Folinate
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: ≦96%
• Appearance: White Powder
• Sample: Available
• Storage: Cool Dry Place
• Shelf Life: 2 Years
• Transport Package: 25kg/Drum
• Specification: 99%
• Trademark: Haibo
• Origin: China
• HS Code: 0000
• Production Capacity: 99999kg/Weeks

Product Description

Calcium folinate CAS NO 1492-18-8 is an antidote of the folic acid antagonists. At room temperature, Calcium folinate CAS NO 1492-18-8  appears as yellowish white to yellow crystalline or amorphous powder, being odorless. It is easily soluble in water, but almost insoluble in ethanol or ether, and easily soluble in sodium hydroxide solution. Calcium folinate is a formylated derivative of folic acid, acting similarly to folic acid, being the activated form of folic acid in the body. 
1.  Calcium Folinate CAS NO 1492-18-8 is mainly used as the antidote of folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim, etc.);
2. Calcium Folinate CAS NO 1492-18-8 can be used for the prevention of severe toxicity after excessive or large doses administration of methotrexate. 
3.  The megaloblastic anemia caused by folic acid deficiency. 
4.  In combination with fluorouracil, Calcium Folinate CAS NO 1492-18-8 is used for the treatment of advanced colon cancer and rectal cancer.
Calcium Folinate CAS NO 1492-18-8 is used for the rescue of the toxicity reaction caused by excessive amount of aminopterin and methotrexate as well as being used for the treatment of giant red blood cell anemia.
The efficacy of folate can offset the effects of folic acid antagonists. The folic acid antagonists rely on binding to folic acid dehydrogenase (DHFR), thereby preventing folate from converting to folic acid. Medically, after the chemotherapy of methotrexate, the Calcium folinate CAS NO 1492-18-8 can be used to reduce methotrexate toxicity. Calcium folinate can be used to enhances the cytotoxic effect of 5-fluorouracil in anticancer fields.

 

 

Analysi	Specifications
Assay	≥99%
Appearance	White powder
Loss on Drying	≤1.0%
Ash	≤1.0%
As	≤2.0ppm
Pb	≤2.0ppm
Insoluble impurity content	≤0.05%
Total Plate Count	≤1000 cfu/g
Yeast &. Mold	≤100 cfu/g
E.Coli	Negative
Salmonella	Negative
Conclusion	Conform USP Standard.
Storage condition	Store in cool & dry place, Keep away from strong light and heat.
Shelf life	2 years when properly stored.