| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
|
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Biktigravir (BIC) is a second-generation integrase chain transfer inhibitor (INSTI), which has been approved for use in fixed-dose combination with emtricitabine and tenofovir alafenamiChemicalbookde for HIV treatment. The first-generation resistant strains have effective antiviral activity INSTIs in vitro.
Function of Bictegravir
Biktigravir mainly clears the liver through cytochrome P4503A4 (CYP3A4) oxidation and UDP-glucosyltransferase 1A1 (UGT1A1) glucuronidation. Therefore, due to the significant reduction of Biktegravir blood Chemicalbook clear exposure, the use of potent inducers of UGT1A1 and CYP3A4 (such as rifamycin/anticonvulsants) should be avoided. Chelating with polyvalent cations can reduce absorption; otherwise, there is little interaction between the drug and the drug.
Application of Bictegravir
Bictegravir (BIC) is a new type of integrase inhibitor, a new research drug of integrase inhibitor discovered by scientists. As of June 2016, Bictegravir (BIC) was used as a single-tablet regimen in combination with Tenofovir Alafe Chemicalbooknamide Fumarate (TAF) and Emtricitabine (FTC) for the treatment of HIV-1 infection, BIC/ In the 48-week Phase III clinical trial of FTC/TAF, it was found that it has a high virus inhibition rate, which can inhibit 97% of the virus, and no adverse reactions have been found. It is less toxic to bone and kidney, and may become the most Competitive anti-HIV drugs.
| Item | Test Standard | Testing Result | |
| Assay | 99% | Complies | |
| Apperence | White Powder | Complies | |
| Particle Size | 100% pass 80 mesh | Complies | |
| Oder | Characteristic | Complies | |
| Taste | Characteristic | Complies | |
| Loss on Drying | ≤5.0% | 2.20% | |
| Residue on Ignition | ≤0.1% | 0.05% | |
| Residual | ≤0.1% | Complies | |
| Residual Ethanol | ≤0.5% | Complies | |
| Heave Mentals | ≤10ppm | Complies | |
| Na | ≤0.1% | <0.1% | |
| Pb | ≤3 ppm | Complies | |
| Total Plate | <1000CFU/g | Complies | |
| Yeast & Mold | <100 CFU /g | Complies | |
| E. Coli | Negative | Complies | |
| Salmonella | Negative | Complies | |
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