| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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Domperidone is a peripherally selective dopamine D2receptor antagonist developed by Janssen Pharmaceutica that is used as an antiemetic, gastroprokinetic agent, and galactogogue.It may be administered orally or rectally, and is available in the form of tablets,orally disintegrating tablets (based on Zydis technology), suspension, and suppositories.The drug is used to relieve nausea and vomiting; to increase the transit of food through the stomach (by increasinggastrointestinal peristalsis); and to promote lactation (breast milk production) by release of prolactin..
Function of Domperidone
There is some evidence that domperidone has antiemetic activity.It is recommended in the Canadian Headache Society's guidelines for treatment of nausea associated with acute migraine.
Application of Domperidone
Domperidone can be used to relieve gastrointestinal symptoms in Parkinson's disease, because, even though it blocks dopamine receptors (which would be expected to worsen Parkinson's disease), it does not cross theblood-brain barrier (the barrier between the blood circulation of the brain and the rest of the body).In addition to this, domperidone may enhance the bioavailability (effect) of levodopa (one of the main treatments in Parkinson's disease). Although these features make domperidone a useful drug in Parkinson's disease, caution is needed due to thecardiotoxic side effects of domperidone especially when given intravenously, in elderly people and in high doses (> 30 mg per day). A clinical sign of domperidone's potential toxicity to the heart is the prolongation (lengthening) of the QT interval (a segment of the heart's electrical pattern)...
| Analysi | Specifications | |
| Assay | ≥99% | |
| Appearance | White powder | |
| Loss on Drying | ≤1.0% | |
| Ash | ≤1.0% | |
| As | ≤2.0ppm | |
| Pb | ≤2.0ppm | |
| Insoluble impurity content | ≤0.05% | |
| Total Plate Count | ≤1000 cfu/g | |
| Yeast &. Mold | ≤100 cfu/g | |
| E.Coli | Negative | |
| Salmonella | Negative | |
| Conclusion |
Conform USP Standard.
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| Storage condition |
Store in cool & dry place, Keep away from strong light and heat.
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| Shelf life |
2 years when properly stored.
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